I agree sounds like something wrong with your water parameters such as high levels of ammonia nitrite or nitrate or you pH and KH could be to low that why you had a mass die off of your guppies and Molly with out noing your water parameters ammonia nitrite nitrate pH kH it difficult to diagnose if it were ammonia or nitrate or nitrite poisoning the most effective treatment is aquarium salt 1 table spoon for 1 gallon it help to speed up the removal ammonia from fish blood and it acts as a natural barrier thought chloride ions to prevent the uptake of nitrite and nitrate @ScandiDefense