The day after starting the med trio on my tank, it looks like my bacteria took a bit of a hit. Not showing any ammonia but the water got pretty cloudy and I had a bit of a nitrite spike. It was up to about .25 ppm so I added some Fritz complete but after a few hours, it wasn't really having an effect. The next day, I noticed two of my guppies getting a little red around the gills so I decided to do a water change. I only changed out about 3 gallons in a 20 gallon but it seems to have done the trick. Will that water change have an overall effect on the whole medication process?
