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Connor Elliott
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Your fish cannot become "immune" to a medication. The medication can be the wrong kind for whatever you are trying to treat.

Salt is often the easiest blanket resort for unspecified freshwater fish diseases. I sail in both fresh and salt water--boats that travel back and forth regularly have nothing growing on the bottom. This illustrates why we use salt--it is poison to fresh water life. We are counting on the fish being more tolerant to the salt than the disease. 

If you have a specific set of symptoms you are trying to treat you could try listing them and see if someone has suggestions.

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