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Hello Everyone. I'm very new to the hobby and I'm really stressed and horrified right now. I really need help. I hope someone has experienced this and can share how they dealt with the situation. I have only done the med trio on panda cories, albino cories, black neon tetras, zebra danios and peppered cories (on separate occasions). Only the peppered cories had such drastic effect on these meds. I am baffled because I got them from a hobbyist. Before the trio, I observed them for almost 2 weeks fed them regularly (frozen brine shrimp, shrimp sinking pellets, micro pellets) and made sure the water was clean. I used test strips as well as the API Master Kit constantly and water change accordingly. (0Nitrite 0Ammonia) I noticed the peppered cories were energetic, eating, very responsive, looked way healthier than the fish I got from big pet stores (such as panda, albino cories, black neon tetras) so I was very confident to do the med trio. I have a 20Gal Tank so I put 10ml Ich-X, 2 Packets of both Paracleanse and Maracyn. I have an airstone running, heater, filter (I took out the carbon for the meds), thermometer, live plants, hiding places. I currently have small zebra danios, and pepered corydoras in this tank. Only a few hours after the meds (nitrite .25 & ammonia 0) I noticed all the peppered cories seemed like they all had swim bladder disease. For example, they're like swimming on the moon, like the gravity is working against them, some would float just still on top then after a quick nudge from another cory or me they would swim slowly to the bottom, a few make it okay to the bottom, while the rest just let themselves go back up again. Their eyes are still moving, still breathing it's just not normal. I had the lights off and left them there tried to not stress them more. After 10/12 hours or so, the situation seemed worse, so I did 20/30% water change and put the carbon filter back on. I was so stressed going to bed because I didn't want to wake up to dead cories. More than 24 hours has passed and still no deaths but I did another 20/30% water change. I think the cories are still getting worse I can't really tell at this point. I'm going to do more water change later. Has anybody experienced this? I've only found one forum just like my situation The mixed responses I've been getting: never a good idea to medicate fish when you don't know what's wrong with them, cories are scaleless and don't tolerate meds well, you're better off putting them in a tank for weeks and watching them in the future now that I reflect on my experience I have lost 4 panda cories while on the med trio but I thought that was because they were sick and weak already when I got them *3 albino cories, 2 panda cories, 6 black neon survived my first med trio don't overdo dosing meds, start low and work up stress from uncycled tank and meds at the same time I made sure with both test strips and API Master Kit that nitrites & ammonia was 0 before I decided to do the trio. Although, I don't think my tank was fully cycled - however, my fist batch of fish that I did the med trio on were also on an uncycled tank but none of them floated like how the peppered corydoras reacted to the med trio Are there other ways to quarantine my peppered corydoras now? Aside from fully cycling a quarantine tank, what could I have done different?