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Originally I thought my silvertips were bullying on of their kind into stress and not eating until it wasted away. They did bully it, and it withdrew and hid away from the rest, not getting as good feeding opportunities. Now having had the fish for about a year, another one of the silvertips is wasting away. This time I have managed to catch and isolate it, along with another one that was exhibiting some odd behavior, seemingly the beginning of wasting away and withdrawing. Oddly enough the fish that was only starting to show the signs of something being wrong ended up worse after isolation. Maybe the stress of being captured and lifted out (it was an easy catch, no chasing, just scooping it out) was too much and the fish just lay on the bottom of the isolation unit and has later died. Water parameters (using a test strip so it's not exactly accurate): NO3 25 NO2 0 GH 6 KH 6 CL2 0 pH 6,8 - 7,0 (I have a CO2 system and monitoring system that automatically opens the valve to adjust the pH) Temp 22,3 - 23,5 degrees C or 71,6 - 73,4 F (I have a Fluval heater that shows the temperature at the back (hotter), and the other reading is from the temperature sensor of the CO2 computer near the electrode at the front) Overall the symptoms I have been able to catalogue are isolation, emaciation, stringy poo hanging from the fish, dragging their tail when swimming, swimming near the surface, not being able to swallow food (the really skinny ones still went for the food, they just spat it out almost immediately) and lack of appetite (before isolation) on the one fish that died after isolation. In addition to the fish that clearly have been sick, it appears some of the silvertips are not growing even nearly as well as others. After about a year some are over twice the size of others. Which could also be something to do with parasites leeching away nutrients. The tank is fairly large 525 liters (115,5 gallons) by outer measurements, but due to plants and rocks and driftwood the internal volume is a fair bit less. As far as I can tell, invertebrates and armored catfish and loaches tend to react negatively to parasite medication. I'm not that attached to the snails in the tank sentimentally, but obviously I'd like to avoid killing them if possible. Also there is the dread of about 10 billion malaysian trumpet snails rotting and polluting the water in the tank. I also have some cories and 3 albino spotted hoplos in the tank, and those I definitely don't want to lose. I also have a 15+ years old kuhlii loach I'd like to keep among the living. Now, what to do? Fritz ParaCleanse doesn't appear to be available in my country. Esha -ndx is generally well recommended but might be harmful to the armored catfish. I could always just treat the sick fish separately, but that is just putting out fires instead of actually improving the conditions of the fish that most likely are all already affected by the parasites. On that topic, is it species related or should I assume all fish irrespective of species are infected? Sorry if this is a bit of a mess, I tried to give all the relevant info I could think of. I'll give more if needed, obviously. The image is very much out of focus but I just couldn't get the camera to focus on the small fish that kept moving. As far as I can tell the skin is fine and healthy, It's more of an indication of behavior and overall wasted condition. Seems I can't add the gif to this post, I keep getting an 'unknown error' notification. So I attached a blurry still from a blurry video instead... The color on the image is off, the fish is silvery in real life.